Franklin I Aigbirhio Selected Research

Inflammation (Inflammations)

4/2024	MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial.
4/2024	Are central and systemic inflammation associated with fatigue in cerebral small vessel disease?
1/2023	Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.
9/2022	MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
1/2022	Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
1/2021	Microglial activation and blood-brain barrier permeability in cerebral small vessel disease.
12/2018	Early microglial activation and peripheral inflammation in dementia with Lewy bodies.
3/2016	Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia.

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Franklin I Aigbirhio Research Topics

Disease

11	Neuroinflammatory Diseases 09/2023 - 01/2018
10	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 07/2011
10	Cognitive Dysfunction 01/2023 - 01/2016
9	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2024 - 01/2017
9	Dementia (Dementias) 09/2023 - 07/2011
8	Inflammation (Inflammations) 04/2024 - 03/2016
8	Down Syndrome (Down's Syndrome) 11/2022 - 07/2011
8	Stroke (Strokes) 10/2017 - 01/2005
7	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 01/2017
7	Hypoxia (Hypoxemia) 01/2017 - 07/2006
6	Tauopathies 01/2022 - 01/2017
6	Atrophy 01/2022 - 01/2019
6	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2019 - 04/2007
5	Corticobasal Degeneration 04/2024 - 10/2020
5	Frontotemporal Dementia (Semantic Dementia) 01/2023 - 10/2018
5	Ischemic Stroke 01/2018 - 01/2005
5	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 03/2015 - 04/2009
4	Parkinson Disease (Parkinson's Disease) 09/2023 - 01/2021
4	Infarction (Infarctions) 03/2016 - 03/2013
3	Disease Progression 01/2022 - 01/2017
3	Ischemia 01/2020 - 01/2016
3	Necrosis 12/2018 - 04/2007
3	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2016 - 01/2008
3	Craniocerebral Trauma (Head Injury) 07/2011 - 06/2002
2	Mitochondrial Diseases (Mitochondrial Disease) 05/2021 - 06/2013
2	Brain Hypoxia (Cerebral Hypoxia) 10/2017 - 04/2007
2	Hyperoxia 01/2017 - 01/2008
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 06/2015 - 05/2014
2	Nervous System Diseases (Neurological Disorders) 05/2015 - 06/2013
2	Cerebral Hemorrhage 01/2015 - 05/2014
2	Amyloid angiopathy 01/2015 - 01/2014
1	Huntington Disease (Huntington's Disease) 05/2024
1	Fatigue 04/2024
1	Lacunar Stroke 09/2022
1	Pathologic Processes 09/2022
1	Cerebral Cortical Thinning 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2021
1	Intracranial Hypertension 01/2020
1	Asymptomatic Diseases 01/2019
1	Mood Disorders (Mood Disorder) 01/2019
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 10/2018
1	Primary Progressive Aphasia 10/2018
1	Brain Ischemia (Cerebral Ischemia) 01/2017
1	Proteostasis Deficiencies 01/2017
1	Hyperaldosteronism (Conn Syndrome) 11/2016
1	Cushing Syndrome 11/2016
1	Adrenocortical Carcinoma 11/2016
1	Breast Neoplasms (Breast Cancer) 06/2013

Drug/Important Bio-Agent (IBA)

23	Amyloid (Amyloid Fibrils)IBA 04/2024 - 07/2011
14	Proteins (Proteins, Gene)FDA Link 05/2024 - 09/2008
10	Oxygen (Dioxygen)IBA 01/2020 - 06/2002
9	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2017
8	LigandsIBA 05/2024 - 03/2011
8	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2022 - 07/2011
7	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 09/2023 - 01/2018
5	fluoromisonidazoleIBA 10/2017 - 04/2007
4	Methylphenidate (Ritalin)FDA LinkGeneric 03/2015 - 04/2009
3	tau Proteins (tau Protein)IBA 09/2023 - 12/2020
3	SynucleinsIBA 01/2022 - 01/2021
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 06/2002
2	Minocycline (Cyclops)FDA LinkGeneric 04/2024 - 09/2022
2	C-Reactive ProteinIBA 04/2024 - 12/2018
2	CytokinesIBA 09/2023 - 12/2018
2	1- ((3- (methylpyridin- 4- yl)methyl)- 4- (3,4,5- trifluorophenyl)pyrrolidin- 2- oneIBA 01/2022 - 01/2020
2	PK 11195 (PK11195)IBA 12/2020 - 01/2020
2	Carbon DioxideIBA 01/2020 - 06/2002
2	Amyloid beta-PeptidesIBA 12/2019 - 01/2019
2	CarbonIBA 01/2014 - 07/2011
2	Dopamine (Intropin)FDA LinkGeneric 11/2013 - 03/2011
2	Therapeutic UsesIBA 11/2013 - 07/2013
1	A-factor (Streptomyces)IBA 01/2023
1	Liposomes (Liposome)IBA 01/2022
1	splenotritin (TP3)IBA 01/2022
1	LipopolysaccharidesIBA 12/2021
1	Indicators and Reagents (Reagents)IBA 07/2021
1	Polytetrafluoroethylene (Teflon)FDA Link 04/2020
1	alpha-SynucleinIBA 01/2020
1	TRAM 34IBA 10/2019
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2019
1	Macrophage Colony-Stimulating FactorIBA 12/2018
1	neuromelaninIBA 10/2018
1	DNA-Binding Proteins (DNA Binding Protein)IBA 10/2018
1	Monoamine Oxidase (MAO)IBA 10/2018
1	Phospholipases (Phospholipase)IBA 01/2018
1	Protein AggregatesIBA 01/2017
1	platinum oxideIBA 01/2017
1	metomidateIBA 11/2016
1	Hormones (Hormone)IBA 11/2016
1	Glycogen Synthase Kinase 3IBA 05/2015
1	Glycogen Synthase (Synthase I)IBA 05/2015
1	TritiumIBA 01/2014
1	AutoreceptorsIBA 11/2013
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 06/2013
1	CationsIBA 06/2013
1	triphenylphosphoniumIBA 06/2013
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 06/2013

Therapy/Procedure

10	Therapeutics 09/2023 - 07/2006
1	Immunomodulation 01/2021
1	Drug Therapy (Chemotherapy) 01/2019
1	Thrombectomy 01/2018